“Can I take Zithromax and alcohol together?” One of the most common questions I get asked is whether it is OK to drink alcohol while on antibiotics. I’m not really sure why so many people are really concerned about whether it is OK to drink alcohol while taking most antibiotics but there is a persistent concern among the general public that this is a big problem. The short answer is that the risks of drinking alcohol while on Zithromax, as with most other antibiotics is pretty minimal. With Zithromax the primary concern is that like other macrolide antibiotics Zithromax can cause upset stomach, dizziness and vomiting. These same problems are common effects of alcohol, and so the additive effect of using the combination of Zithromax and alcohol may be increased. There is little major concern. The effectiveness of the antibiotic is not diminished, there are no major consequences of the combination in most patients, and overall the combination of Zithromax and alcohol is most often not a big concern. You should not drink a lot of alcohol, i.e. get really drunk, while taking Zithromax, because it is better to get rest and take good care of yourself in order to give your body the things it needs to get well. Overall chicken noodle soup is probably a better thing to take with your Zithromax than alcohol, but you’ll probably get well either way.