Viibryd: A New Antidepressant without Sexual Dysfunction?

This month a new antidepressant came to market.  Viibryd continues the trend of ever stranger new drug names (generic name vilazodone) and comes with the claim that it won’t lead to sexual dysfunction in the vast majority of users.  Whether this turns out to be the case will likely determine whether Viibryd is a hugely popular new drug or just another strangely named addition to an already saturated field of SSRI type antidepressants.  Viibryd is technically in a class of its own, having both serotonin reuptake properties and functioning as a post synaptic partial serotonin agonist.

The SSRI drugs prevent the reuptake of serotonin from the space between nerve endings, and lead to an increased concentration of serotonin in this space.  Viibryd in addition to this function is a partial serotonin agonist.  An agonist is any drug that simulates the activity of a chemical in the body.  This additional function could at least in theory alter the usually side effects of an SSRI as well as alter its potential benefits.

In two relatively small studies Viibryd was found to be effective as an antidepressant, but had a very low incidence of sexual dysfunction.  Specifically the incidence of orgasmic dysfunction in women and ejaculatory delay or dysfunction in men was less than 3% and very near the rates with placebo.  The published rates of these side effects with all of the currently available SSRIs, including fluoxitine (Prozac), sertraline (Zoloft), paroxitine (Paxil) and others, as well as with the SNRIs like venlafaxine (Effexor) and Cymbalta are greater than 15%, and in my experience prescribing these drugs are even higher.  By far the most common SSRI and venlafaxine side effects are various aspects of sexual dysfunction, especially orgasmic dysfunction.  These are common enough and annoying enough that I often see patients in the office who have stopped their antidepressant medications because of their sexual dysfunction side effects.

The major factor that Viibryd is going to have to overcome is that there are several highly effective generic SSRI antidepressants on the market that are available on the discount pharmacy $4./ month offerings.  As a branded antidepressant which will almost certainly be much higher priced Viibryd is going to have to show a clear benefit to gain traction in this highly competitive and saturated market.  If Viibryd is found by patients and physicians to be as effective as the currently available SSRIs at treatment of depression, and really not cause orgasmic dysfunction in women and have a very low incidence of sexual dysfunction overall it is going to be a nice addition to our options for treatment of depression.  I’ll reserve my judgement at this time, as prior releases of new SSRIs were touted as having lower likelyhood of these side effects.  I remember the claim that Celexa side effects of sexual dysfunction were low, but in aftermarket experience Celexa (citalopram) turned out to cause only minimal if any less frequent sexual dysfunction that the SSRIs already on the market.

Viibryd is reported to have a bit higher incidence of gastrointestinal side effects than most of the SSRIs, and to avoid these side effects it is recommended that patients taper up fairly quickly in dosage.  It will be interesting to see if this leads to taking an extra week or two for clinical efficacy.  One of the issues we face in prescribing antidepressants in general is that they don’t work immediately, rather tend to take 2-4 weeks to start to help.  Adding another week or two of ramp up in dosing may be a bit of a drawback to acceptance or Viibryd by patients.  I expect the role of Viibryd to be as a second choice of an antidepressant in patients who experience bothersome sexual dysfunction on another SSRI, and Viibryd is tried as a way to avoid that problem.

Viibryd was developed by Clinical Data which was acquired by Forrest Laboratories earlier this year.  Forrest also has Lexapro and Celexa as branded antidepressants, and is expected to make a big marketing push for this new product.  From the surge of drug reps at my office it certainly seems like they are throwing all of their weight behind I’m anxious to see if Viibryd lives up to its marketing hype and really does work without causing sexual dysfunction.  If so I expect it to be hugely successful.  The market for antidepressants is huge, with Effexor and Cymbalta, two branded SNRIs having sales of over $2 billion annually.  Expect the $1.1 billion Forrest paid for Clinical Data to be a bargain if Viibryd works as advertised.  I plan to go slow and see how this all pans out.


170 Responses to Viibryd: A New Antidepressant without Sexual Dysfunction?

  1. I have been o viibryd for 2 years and. Have to say it made me want to live Again. My mom and grandmother died and I was severely depressed! It took about 2 months to really get in my system and I am on 40 mill. Thank God for whoever made this drug. I feel like I have a future again

  2. I have been on Viibrid now for 3 months. Like others, I went by prescription blister packs of 5, to 10, to 20, then to 40 mg a day. What I have noticed is a better calmness generally and a happier mood. BUT, I am going to ask my Dr. To remove me off Viibrid due to the 3 major side effects that I can’t deal with– dreams every night that are the most vivid nightmares I have ever had, plus loss of sexual sencivity to the point I never get errections, and the final unbearable, urination very often and without feeling. Meaning I can’t tell or feel actually urine passing through my penis. I feel very close to in continuance at times. There has to be a better medicine for me.

  3. I have been on Viibryd for 6months now and it has worked really great for me. I had the upset stomach for the first few days but it normalized. It definitely affected my mood immediately and I was no longer having hopeless, intrusive thoughts within the first few days. It did make me feel a little manic whenever I increased the dosage, and I found that 40mg was too much so went down to 20. I have had NO sexual side effects which has been great. The worst side effect was the sleep paralysis I had when I was taking 40mg. I would have a bad dream and my mind would wake up, but I was unable to move my body to awaken from the dream. That was a little disturbing the first time it happened because I didn’t know it was a common occurrence. I had that happen a couple more times and went down to 20mg. Also I have found that taking my dose in the middle of the day is the best time for me. Otherwise I would get a little drowsy and have a hard time focusing if I take it in the morning. I make sure not to miss a dose because I am unable to sleep if I do. It took a while to get everything figured out, but I am really thankful it has worked to ease my depression, and my weight and sexual function have remained unaffected.

  4. I had a medical scare and was have trouble recovering emotionally. I was given Viibryd to take to help. After 3 days I stopped taking completely and do not want to restart as I did not like the side effects I was feeling and got scared. I stopped taking this 4 days ago and only took 3 10 mg dosages. I know I was on the low dosage and not the 40 mg but am I out of the woods for side effects at this point? If not can I take Xanax to help the feeling?

  5. During the 6 months I have been on 10 mgs of Viibryd, I have packed on 17 lbs, have zero sex drive (possibly from the weight gain, because I still have sexual dreams) and have decided to wean off this drug. At the start my doctor reassured me that Viibryd wouldn’t cause weight gain. Over the course of 6 months, I have slowly gained weight and feel horrible about my appearance. Whenever I mention my side effects to my doctor, she always says “Well, you/re feeling better, so what’s a little weight gain?”

    I am now convinced that every time Big Pharma develops a new, unpatented antidepressant, they claim “No weight gain/sexual side effects!!!” because they KNOW they can get doctors to push this new, expensive med before the truth slowly gets around. They also KNOW that those 2 issues are most patient’s biggest concerns!!! LIES!!! 20 years ago, I believed my doctor when he said the same exact things about Prozac. After 2 years of gaining at least 25 lbs, craving carbs like a maniac, and feeling like a munic zombie, I decided to search for the truth, and lo and behold, I found many other people having the same experience!!!! This will be the last time I fall for the Big Pharma Lies!!!

  6. Knr: Although the GI side effects are proported to be “transient” by the manufacturer I have has a few patients who have not been able to tolerate these issues long enough to really see if they would resolve. You are not alone. DrP.

  7. I am a Registered Nurse of five years. I have been on antidepressants for 12 years now. I have tried a mass amount of brands. I have ZERO interest sexually for about five years now due to long term use of antidepressants I have recently switched to Vibbryd for a week now. I have a great deal of Gastrointestinal side effects, severe bloating. Does this eventually go away??!!

  8. I have been taking viibryd for over a month now. and it clams it does not have sexual side effects. Or other side effects and it does. I’m tired of being lied to. I have tried so many antidepressants none have helped maybe it helps with some people and I am happy for those that it works for. all it does it takes over your life. I’m an adult and most of all I feel bad for small children and teens. Me and my husband do a lot of research now. The meds I am now it will take a while to get off of them. It will be hard. But for those who are un happy with any medication do your own research before taking anything. The best of luck to everyone. And God bless. Jeanette

  9. Lori: Headache is not listed in the prescribing reference as a common side effect, but essentially any medication can cause nearly any side effect in a small percentage of cases. You should discuss this with your prescribing physician. DrP.

  10. Been on antidepressants for 15 years. I have tried many, many kinds. They have all caused sexual dysfunction. My dr told me about this one and it’s claim for reduced sexual side effects. I am on 20 mg tablet now after ramping up for week. I am waking up with a headache now for second morning. Could his be the medication?

  11. Viibryd does cause sexual side affects………also has caused me some nerve and muscle pain. Now on 10mg to see if it goes away or I will need to stop it all together.

  12. GB: Get back to your doctor ASAP, obviously the Viibryd is not helping. It may be that something like adding second medication of a different type may help along with one of the other antidepressants. Don’t give up. DrP.

  13. I have been on Viibryd now for about 8 weeks. I do not know about others, but I can say with certainty that this medication does have sexual side effects. In fact the worst I have ever experienced and I have been on more than 15 different antidepressants over about 20 years. I have no appetite whatsoever, my sleep has been severely impacted. My digestive system is a mess and the worst thing is that the depression is worsening rather than improving. This drug is not helping me at all and frankly I am losing hope there is any help for me. I have had success three previous times with Wellbutrin, but this most recent time I was prescribed it my depression worsened significantly. Now the Viibryd is not helping but harming. I think it is over for me.

  14. I am now up to 20 mg viibryd (the dose my gynecologist wanted me to be) after 4 weeks and I have had some gastrointestinal side effects. I also feel the urge to urinate more frequently than usual. I also don’t get as much sleep since taking this compared to 50 mg of Zoloft. I am a 35 year old married female with no children.

  15. That is scary about your sister, Brenda. I hope she is alright. I just started Viibryd about 2 weeks ago. Was on Zoloft (High Dosage) for several years. Tapered off onto this within 7 days. I did realize a gain in sexual interest. Big plus. But I also then spent 4 days with gastro issues after being on this by itself. Today I double by pill strength and am wondering if I will have the gastro issues or if that was from ending the Zoloft. Today I go from 20mg x 2/day to one 40 mg once a day. I was on 60mg of Zoloft (20mg x 3 day) but 20 mg of Viibryd seemed much ‘stronger’ then the Zoloft. I really don’t have another word other then it seems ‘Turbo’ compared to Zoloft. I am a bit worried on taking a 40mg dosage at once after reading Brenda’s story. I would like to keep bladder control and the use of my extremities. I take it for post traumatic stress after the loss of a leg. I don’t need to lose the rest of my digits. I hope that is a freak side effect. I do take what some Doctors consider a high dosage of Moriphine which makes me sleep. I haven’t heard or read of Viibryd causing sleeping as Brenda describes. When I sleep I have two goles in mind…rest my body and to wake up. Took the 40mg now and am going to take a nap. Wish me luck. Doctors orders.

  16. I’ve been taking Viibryd for about 4 months now. I would say that it definitely does not have the same sexual side effects as other anti-depressants based on my own experience (no desire to somewhat interested). However, I want to slowly decrease my doses and eventually discontinue this medication because I get electrical zaps in my head around the time of my next dose. Any intense emotions like being frustrated or happy or sad make the zaps more intense. If I take my next dose, I’m fine, but I don’t like being reminded in a very intense way it’s time to take my next dose of medicine.

    I guess I would take the sexual side effects of other more stable anti-depressants than have this new side effect that is very uncomfortable and that I’ve never had from other types of anti-depressants.

  17. My sister is having neurological issues, she stopped walking 1 month ago, and has no feeling in her feet. Her hands tremble like Parkinson. She was diagnosed w9ith conversion disorder and clinical depression. Thursday (3 days ago) her PCP changed her antidepressaNT to Viibryd. Today (Saturday) she complained of nausea and dizziness. I got her from the wheelchair to the couch and she passed out and fell on the floor. I called 911 and the hospital admitted her. She is still not awake 6 hrs later. They said loss of function in extremities and loss of bladder control are coomon side effects of viibryd. She is on the step up acclimation, 7 days on low dose and increasing. Have you seen this occur before. My sister is 35 yrs old, and only take vicodin/motrin, clarispodol and antidepressants. No hx of chronic illness only mild scoliosis, and bulging vertabrae. Thank you for your help.

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