Most people use non-prescription medications without giving much thought to the potential side effects or problems that may be associated with their use. Here are 5 pretty popular OTC meds you should avoid, and better alternatives. I bet most of you use one or more of these. Neosporin, Topical Vitamin E, Afrin nasal spray (or other short acting nasal decongestant sprays), daily headache medications, and sedating antihistamines.