I really discourage the use of pseudoephedrine and phenylephrine as a decongestants, especially in adult men. The biggest reason is that they just don’t work very well, and the potential side effects seem to outweigh the benefits. Friday in the office I saw a man in his early 50’s with acute urinary retention. He had been having some cold symptoms and was using OTC cold meds that contain both antihistamines and decongestants. He had been having very mild prostatism symptoms for a year or two prior to this visit, but never significant urinary symptoms. He was drinking lots of water, because he thought he might have a bladder infection causing his difficulty urinating. By the time he came to the office he had been complete iunabloe to void for 9 hours, and had a painful distended bladder. I needed to place a urinary catheter to drain over a 1200 mililiters of urine, and needed to leave the catheter in place over the weekend to allow the bladder to regain its tone. I had him stop the decongestants, and suspect he will be able to void fine after a few days off the cold meds.
Over the years I’ve seen several cases of acute urinary retention, and more often than not they have been related to medication use. Although the list of medications that can cause urinary retention is long in recent years, since we stopped using as many tricyclic antidepressants and anticholinergic medications for bowel problems, decongestant use is by far the biggest culprit.
In addition to causing occasional acute urinary retention, these decongestants can cause anxiety, insomnia, and irritability especially in children. They can raise blood pressure especially in hypertensive patients, and can lead to rebound nasal congestion when stopped if used for more than a few days. Millions of us subject ourselves to these risks for medications with essentially no evidence that they shorten the course of congestion with a cold or prevent complications like sinusitis or otitis media. There is also very little evidence that they even help with symptoms of congestion. My guess is that if men realized that the cold medicine they use could lead to having a urinary catheter for a few days they would stay far away from that aisle in the pharmacy.

