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Category Archives: Today In the Office

Subconjunctival Hemorrhage: Just a Broken Blood Vessel in the Eye

Resolving Subconjunctival Hemorrhage (3 days old)

Today in the office I saw the patient with the subconjunctival hemorrhage, or broken blood vessel in the eye,  in this photo.  It is always fun to see subconjunctival hemorrhage in the office because it is so easy to diagnose and the news is universally good.  Nothing else really looks like a subconjunctival hemorrhage, but it certainly gets your attention if you have one.  If you think of it as just a broken blood vessel in the eye you can imagine how it will look.

The part of the eye that can be seen from the outside consists of the iris and the pupil which are covered by the cornea, and the white part of the eye, the sclera, which is covered by a very thin layer of clear tissue called the bulbar conjunctiva.  The conjunctiva covers the white part of the eyeball and wraps under the eyelids where it is called the palpebral conjunctiva.  The tiny blood vessels that course through the conjunctiva are usually barely visible.  When the conjunctiva is inflamed from allergy, viral or bacterial infection, or other causes of irritation these vessels become engorged and the eye appears pinkish.  This is sometimes called pink eye.

When one of these tiny blood vessels in the bulbar conjunctiva breaks a tiny drop of blood leaks into the space between the conjunctiva and the tough leathery white of the eye.  This blood spreads into a very thin but bright red layer making it look like the whole eye is covered with blood. It looks just like what it is, a broken blood vessel in the eye.  The blood can spread to the whole white area of the eye, or just involve either the inner aspect or the outer aspect of the eye.   This condition is called a subconjunctival hemorrhage.  The “sub” prefix means beneath or under the conjunctiva.

There are several common causes of subconjunctival hemorrhage, but often a person has no idea how the blood vessel was broken.  The most classic of the causes of subconjunctival hemorrhage is labor in pregnant women.  The violent pushing required to expel the fetus commonly causes a broken blood vessel in the eye.   Other fairly common reasons people get a broken blood vessel in the eye are minor trauma, i.e. being poked in the eye, blunt trauma, i.e. being punched in the eye, and sneezing, coughing or rubbing an eye that itches from allergies.

A subconjunctival hemorrhage gradually clears up over a few days to a few weeks time.  The initial bright redness disperses and the blood is reabsorbed.  Usually within 3-5 weeks the redness is completely gone and recovery is complete.  In situations where a person is on an anticoagulant like warfarin or Pradaxa, or an anti-platelet agent like aspirin or Brilinta the bleeding from the broken blood vessel in the eye may be more extensive than usual, but even in these cases the blood usually is reabsorbed fairly quickly.

It is important to differentiate subconjunctival hemorrhage from hyphema.  Hyphema is bleeding into the anterior chamber of the eye behind the cornea, and appears like blood is filling up the space behind the cornea.  Hyphema is an ophthalmologic emergency and needs opthamologic consultation.  Subconjunctival hemorrhage does not affect vision, whereas hyphema usually blocks the visual field.  It is not usually difficult to tell the difference but if there is any question you should definitely see your physician to have your eye examined.

The bright redness of a subconjunctival hemorrhage is not at all like the pinkness of conjunctivitis.  Conjunctivitis on close examination looks like the blood vessels in the conjunctiva are more noticible or injected looking.  With subconjunctival hemorrhage it looks like a pool of blood is covering the eyeball, and looks just like what you would expect from a broken blood vessel in the eye once you understand the anatomy of the conjunctiva and the eye.

Check out this related resource on aspirin side effects.

Spironolactone Off Label Use: PMS, Acne, Hirsuitism, Male Pattern Baldness

Today the medical student working with me asked my why a patient was on spironolactone for acne, as she thought this was a potassium sparing diuretic.  Great question as the FDA approved use of spironolactone is just that.  In the office I see far more women on spironolactone these days for acne, facial and body hair, or even for PMS than I see patients on spironolactone for its diuretic properties.  The anti-androgen properties of spironolactone are well known and frequently utilized in off-label prescriptions of this medication.

Hormonal acne has always been among the more difficult types of acne to treat, and in recent years the use of spironolactone for its anti-androgen effects has been found to be helpful for this particular type of acne.  When a woman’s acne is much worse in the week or two prior to her menses or around the time of menopause oftentimes the acne will respond to the anti-androgen effects of spironolactone.  The usual dose is 50-100 mg twice daily.  In adolescents and young women the combination of low-androgenic oral contraceptives is sometimes more effective than spironolactone alone.

The use of spironolactone for suppression of androgenic hair growth by women is also widespread.  Spironolactone can be effective in suppression of facial hair and to a lesser degree body hair.  Again the dose often used is 50-100 mg twice daily.  Polycystic ovarian disease is one of the common medical problems where spironolactone is used for suppression of facial hair growth.

On the other side of hair growth, spironolactone is being used without much evidence to support its efficacy in men with male pattern baldness.   Topical preparations are proported to be helpful for this indication, although I have to say I’m skeptical and the evidence looks pretty sketchy.  Some advocates suggest that adding spironolactone topically to systemic finasteride (Propecia) gives additive anti-androgenic effects at preventing male pattern baldness hair loss.

PMS is a  less well documented and popular use of spironolactone.  Some women find that the drug lessens the severity of the premenstrual dysphoric and fluid retention symptoms.  The primary effect of spironolactone is inhibition of the adrenal hormone aldosterone.  Aldosterone leads to elevation of blood pressure, so inhibition of aldosterone can cause dieresis and so lessen the PMS symptoms of bloating, fluid retention, and premenstrual weight gain.  It is unclear whether the anti-estrogen effects of spironolactone play a role in reducing the emotional symptoms of PMS, or whether any benefit in this regard is related to the diuretic effects.

Traditional uses of spironolactone are more mundane but well documented.  Likely the most common FDA approved uses of spironolactone are to spare potassium loss in combination with a thiazide diuretic, in such fixed dose drugs as Aldactazide and for treatment of congestive heart failure in patients. A commonly noted NEJM article showed that in patients with serious heart failure, LV ejection fraction less than 35%, usually also on and ACE or ARB and loop diuretic like furosemide patients on spironolactone had significantly lower death rates than the control group on placebo.  For more information about furosemide please visit furosemide side effects for a nice resource online.  Other typical diuretic uses of spironolactone are patients with ascites due to cirrhosis of the liver.  The theory behind this is that effects of aldosterone may be harmful to the myocardial cell function.

Spironolactone has potential side effects that can bother patients, and can lead to drug interaction issues.  Common side effects of spironolactone include elevation of serum potassium levels that can be severe at times, Gynecomastia, and diarrhea.  Serious drug interaction side effects can occur with numerous medications, but of special mention are additive potassium elevation effects when used with angiotensin receptor blockers or angiotensin converting enzyme inhibitors, with various other antihypertensive or other cardiac medications.

Spironolactone is pregnancy category D, and carries a black box warning that long term use in rats has been associated with tumor growth and toxicity.

Antibiotics and Alcohol



Among the more common misconceptions I encounter at the office is that somehow the combination of antibiotics and alcohol is a particular concern.  In fact except for a few very specific antibiotics there is no special concern with the use of alcohol and antibiotics.  So where do the rumors about alcohol and antibiotics come from?  Probably from the concern that the side effects of many antibiotics can mimic the effects of drinking alcohol including nausea, vomiting, dizziness and sedation.

The one antibiotic with a contraindication to use with alcohol is metronidazole, better known by the brand name Flagyl, which has properties in common with Antabuse.  Antabuse is a medication sometimes used in alcoholics because it leads to severe symptoms when used with alcohol.  These symptoms can include flushing, sweating, hypotension, nausea and vomiting.  They can be so severe that Antabuse is only prescribed to alcoholics felt to be dependable enough to successfully abstain from drinking while on the drug.

Another antibiotic with the potential for more common antibiotic and alcohol interaction is trimethoprim-sulfamethoxazole.  This medication is more commonly known by two brand names, Septra and Bactrim, and the side effects nausea, vomiting, and headache may be more common with concomitant use.

Tinidazole is an antimicrobial medication used in the treatment of some of the same infections as metronidazole including amebiasis, giardiasis, and trichomoniasis.  It also shares the Antabuse like side effects when used with alcohol with metronidazole.

Other antibiotics and alcohol have no major drug interactions or problems.  The same issues of antibiotics and alcohol are the same as whti the use of alcohol and any other medication.  These include non-compliance due to inebriation, vomiting and therefore lack of absorption of the antibiotic, and lack of sleep, good nutrition and generally not getting rest and nutrition that can help with recovery from infections.

Severe liver disease can be an issue with some antibiotics, but this is more an issue of use of antibiotics in end-stage liver disease from alcohol than with the use of antibiotics and alcohol together.

My advice regarding antibiotics and alcohol is that your best chance to get well quickly is to get lots of rest, to drink lots of non-alcoholic beverages, remember to take all of your prescribed doses of the antibiotic, and if you choose to drink alcohol and take antibiotics use moderation.

Can You Take Zithromax and Drink Alcohol?



“Can I take Zithromax and alcohol together?”  One of the most common questions I get asked is whether it is OK to drink alcohol while on antibiotics.  I’m not really sure why so many people are really concerned about whether it is OK to drink alcohol while taking most antibiotics but there is a persistent concern among the general public that this is a big problem.  The short answer is that the risks of drinking alcohol while on Zithromax, as with most other antibiotics is pretty minimal.  With Zithromax the primary concern is that like other macrolide antibiotics Zithromax can cause upset stomach, dizziness and vomiting.  These same problems are common effects of alcohol, and so the additive effect of using the combination of Zithromax and alcohol may be increased.  There is little major concern.  The effectiveness of the antibiotic is not diminished, there are no major consequences of the combination in most patients, and overall the combination of Zithromax and alcohol is most often not a big concern.  You should not drink a lot of alcohol, i.e. get really drunk, while taking Zithromax, because it is better to get rest and take good care of yourself in order to give your body the things it needs to get well.  Overall chicken noodle soup is probably a better thing to take with your Zithromax than alcohol, but you’ll probably get well either way.

Resource:

Zithromax side effects

Epley Maneuver and BPPV



In a prior post, Epley Maneuver Rocks, I discussed both my personal experience using the Epley maneuver for benign paroxysmal positional vertigo (BPPV) and my experiences in the office.  That post has generated so many off-line contacts that in this post I’ll discuss more about vertigo, BPPV in particular and the Epley maneuver and how and when to use it.  Vertigo is quite common and because treatment of vertigo can be frustratingly ineffective at times patients with vertigo can become very frustrated.  Dizziness and vertigo are common complaints in my office, as they are for primary care providers in general.

When a patient presents with dizziness first I need to assure that they do not have a life-threatening disorder with severe hypotension and shock.  Then the question I need to answer is whether the dizziness is vertigo or lightheadedness.  Vertigo is perceived by patients as a sensation of abnormal motion of some sort, typically as a feeling that they are spinning or that the room is spinning, but sometimes as a feeling of being off balance like they are going to fall to one side or another.  It is often similar to motion sickness for readers who get sea-sick or car-sick.  Other patients describe the feeling of vertigo as being like the feeling of imbalance that they associate with drinking too much and being a bit drunk.  Vertigo is often associated with nausea or vomiting and may sometimes be less severe if they lie or sit perfectly still.  Lightheadedness is the type of feeling you get if you stand up too quickly from lying or sitting, especially if you are mildly dehydrated.

If you feel you have lightheadedness the first thing to decide is whether you are simply a bit dehydrated.  If you suspect dehydration you need to drink more fluids and restore your fluid volume status.  Other causes of lightheadedness include medications, especially anti-hypertension medications, allergic reactions severe enough to cause hypotension, and serious infections.   If it is not clear what is causing your lightheadedness you should consult your doctor and try to find out the cause and get appropriate treatment.

If you have vertigo most of the time you should see your doctor to find out the cause.  Some causes of vertigo are really serious, and it is not a symptom that I can recommend that you try to figure out on your own.  The common causes of vertigo are inner ear viral infections called labyrynthitis or vestibulitis, benign paroxysmal positional vertigo, and Meniere’s disease.  Less common but serious causes can be acoustic neuroma (an auditory nerve tumor), other brain masses including benign and malignant tumors, brain infections like encephalitis, concussions and other head injuries, and other less common disorders.

BPPV is typically worse when turning your head to one side than to the other side, and is common in patients of all ages though more common as you get older.  The Epley Maneuver is a procedure that can be used at the physician’s office or at home to treat BPPV with varying degrees of success.  See the video clip on the prior post for a quick lesson on how to the the Epley maneuver on your own.  Many patients find it more helpful to have the procedure at the doctor’s office because it can make you very vertiginous during the procedure and you may benefit from reassurance and support of your doctor to get through the Epley maneuver.  If you do the Epley maneuver yourself and find no help it is even more important that you see a physician to find out if there may be another cause that needs further evaluation.  Unfortunately the other very common cause of vertigo, acute viral labyrynthitis, may cause vertigo even more severe than BPPV and can be refractory to treatment.  Fortunately acute labyrynthitis usually is self-limited, resolving on its own in a few days to weeks.  We have drugs to help a bit with the symptoms, but none to hurry the cure.

Even though as I implied in my prior post headline the Epley Maueuver Rocks, vertigo definitely does not, and I hope both you and I never have to go through it (again for me).

 

 

Larsen Syndrome: A Rare Disorder I Saw in the Office



This week in the office I had the pleasure of seeing a young woman with Larsen Syndrome.  She started to see me in the office recently after her prior family doctor left the area, and I finally today made time to look at this rare but interesting syndrome.  Larsen Syndrome is a rare autosomal dominant disorder with

Amoxicillin and Alcohol: Is There a Problem?

“Doctor Pullen,  can I take the amoxicillin and alcohol together?  I heard that using antibiotics will prevent the antibiotic from working?”  I get more questions in the office about whether the use of antibiotics like amoxicillin and alcohol are okay to use together. I’m not sure where the concerns about the use of alcohol with antibiotics originated, but with the exception of metronidazole the use of alcohol and antibiotics is really not a major concern. I suspect that the myth that somehow alcohol reduces the effectiveness of antibiotics originated from spouses or parents trying to find an excuse to get their loved one to stop drinking.

Let’s take amoxicillin as an example. Amoxicillin is in the penicillin class of antibiotics that is essentially 100% excreted in the urine unchanged. Alcohol on the other hand is largely metabolized in the liver and so there’s no significant metabolic interaction between amoxicillin and alcohol. A potential concern with the use of alcohol and essentially any medication is that when under the influence of alcohol many patients may be less likely to remember to take their medication and compliance could potentially be reduced. Additionally in alcoholics when drinking heavily may not be getting good sleep, eating properly, and generally taking good care of themselves. These behaviors could lead to poor ability to recover from bacterial infections.

Overall the risk of alcohol and amoxicillin or any other antibiotic except metronidazole is relatively insignificant. When patients ask whether they can drink while taking their antibiotic I tell them that they need to focus on taking good care of themselves by getting rest, drinking plenty of non-alcoholic fluids and that one or two drinks is likely to affect their ability to either fight their infection or to interfere with the therapeutic benefits of the amoxicillin.

Another concern about use of some antibiotics and alcohol is that their side effects can be similar. Examples include doxycycline, erythromycin, trimethoprim-sulfamethoxazole, and the tetracycline antibiotics which can cause nausea and upset stomach, also common side effect drinking alcohol.

As mentioned above metronidazole is the major exception to antibiotics and alcohol use together. Metronidazole has an effect similar to Antabuse;  a medication used purposely to lead to sometimes severe illness symptoms when taken with alcohol. The effects with metronidazole are not as consistent or severe is with Antabuse but metronidazole and alcohol need to be avoided in combination.

So unless you have another reason to abstain feel free to have a  glass of a nice cabernet or a mug of porter while on your amoxicillin.  Just remember to take good care of yourself, and maybe add a bowl of chicken soup.

Resource: Amoxicillin side effects

Azithromycin and Alcohol: Like Most Other Antibiotics and Alcohol It’s no Big Deal



“Is it OK to take azithromycin and alcohol?”  A very common question I hear in the office is if it is a problem if a patient drinks alcohol while taking an antibiotic. It’s not at all clear where the myth started that taking an antibiotic and drinking alcohol is somehow a lot worse than drinking and taking other medications, but it sure seems to be a common concern.  I think it’s a lot like the, “Don’t swim after eating,” myth, it just gets passed from generation to generation as fact.  For almost all antibiotics, with the clear exception of metronidazole, the honest answer is that the risks of drinking alcohol while on azithromycin, as with most other antibiotics is pretty minimal.  (Metronidazole has an antabuse like effect and can cause fairly severe flushing, hypotension, and a really sick sensation if taken with alcohol)  With azithromycin the main problem is that macrolide antibiotics including azithromycin fairly often have side effects of upset stomach, dizziness and vomiting.  These are symptoms also often seen from drinking alcohol, and the combined side effects of using them together may be increased.  There is really no major problem.  The antimicrobial effect of the azithromycin is not reduced and major problems are just not often noted with azithromycin and alcohol used in combination in most patients.  The azithromycin and alcohol combination is most often not a big concern.  Anyone who is sick obviously shouldn’t get drunk, lose sleep, and weaken themselves whether they are on an antibiotic or not.  Every mother and doctor tries to get us to get rest and take really good care of ourselves to allow our bodies to fight the infection and get well.  The benefits of  chicken noodle soup is almost certainly a more beneficial choice to take with azithromycin than alcohol, but even washed down with a beer or wine most antibiotics will still work just fine.

Epley Maueuver Rocks!



I finally tried the Epley maneuver a few months ago after struggling with vertigo for a few weeks.  As a family physician I was certain that I had benign paroxysmal positional vertigo (BPPV), and that it would likely improve if I just waited it out, but I was getting pretty tired of walking around the office like Frankenstein, head held still, trying not to move suddenly.  For years I had been referring my patients with persistent BPPV to ENT doctors for repositioning therapy, but had not been doing it in the office. Most of the time patients just get better in a week or two without specific treatment.

Finally I used Dr. Google to look up home repositioning therapy after one of my younger partners told me about the Epley maneuvers.   These are really pretty simple, and I did them myself with excellent relief.  Within 2 days I was about 95% free of vertigo symptoms.  Yesterday morning I awoke with a recurrence of the vertigo again.  I use my iPhone as my alarm now, and it was lying on the floor charging at the bedside.  On rolling over to turn off the alarm I got so dizzy with the whole room spinning that I had to quickly lie down and let the alarm keep going.  I finally managed to get the alarm off, but felt pretty lousy.  I got to the office and went right to an exam room, and put myself through the Epley maneuvers, with only slight help.  I struggled through a reduced workload day, and last night again did the maneuvers.

I took care last night to avoid rolling to the left, my affected side, and this morning am much better, at least 90% improved, with no true vertigo.  For those readers who say, “What’s vertigo?” first I’m happy for you that you’ve not experienced this miserable symptom.  It is the type of dizziness where there is a sensation of spinning or movement of yourself or the surroundings. It feels like motion sickness, often associated with nausea and severe imbalance.  It can be caused by inflammation or other disorders of the inner ear, particularly the vestibule (semi-circular canals).  BPPV is a type of vertigo where the fluid and tiny granules in the vestibule get out of position, leading to a sensation of motion and vertigo.

I think I managed to practice for 30 years without knowing about the Epley maneuver because John Epley didn’t describe this treatment until 1980, the year I graduated from Med School, and somehow I never heard about it until recently.  The procedure is really simple, though it can produce really miserable vertigo during the procedure for many patients, and can be tough to do without support from a confident helper, like your physician if your vertigo is severe.  It’s also important not to just assume your vertigo is BPPV as there are other more serious causes that may need diagnosis and treatment.  If there is any doubt of the diagnosis see your physician for evaluation.  Here is a You Tube of the maneuver:

 

As you can see, it’s not really difficult to do, and I now often suggest to my patients to do it at home, or sometimes do it with them at the office. Now I can just send them to this post for details :.) For more  information on the Epley Maneuver and vertigo and dizziness see a later post on the Epley Maneuver.

Painless Jaundice

I saw an older male patient yesterday who had painless jaundice.  This is one of the conditions every medical student learns has cancer until proven otherwise.  Although there is a big list of causes of jaundice, in older adults who develop jaundice without having significant abdominal pain a less than acute cause of obstruction of the outflow of bile is the most common cause.  Unfortunately the cause of this obstruction is most often a cancer that blocks the outflow of bile.

This patient had presented to our same day clinic three days previously, and had liver function tests as well as testing for hepatitis A,B and C, as well as an abdominal ultrasound ordered.  The LFTs showed significant elevation of the transaminases, a bilirubin of 5.6, and the tests for viral hepatitis were all negative.  The ultrasound added some hope with a gall bladder full of stones, but no common bile duct stone seen on the scan, and the common bile duct was dilated to 16 mm, far larger than normal.

The anatomy of the outflow of bile from the liver and gall bladder is fairly simple to think about, and the pancreatic duct empties into the common bile duct near where the cystic duct from the gall bladder joins the common bile duct.  The head of the pancreas is near this area, and cancer of the head of the pancreas can cause obstructive jaundice of the bile duct.  Cancers of the gall bladder or common bile duct can also cause jaundice as a presenting symptom.  Cancers metastatic to the liver can also cause jaundice by obstruction of intrahepatic bile ducts.

I’m praying that this patient has a common bile duct stone and obstruction that can be cured with removal of the stone and cholecystectomy, but know that it is likely that the stones are not the problem.

Other causes of jaundice include the many types of cellular inflammation of the liver called hepatitis, overly rapid breakdown of red blood cells called hemolysis that can overload the liver with hemoglobin that is metabolized into bilirubin and can lead to jaundice, bile duct disorders like the autoimmune disorder called primary sclerosing cholangitis, and other causes of bile duct obstruction.  Still common things being common I am anxiously awaiting word from my gastroenterology consultant on the results of the ERCP (endoscopic retrograde cholangiopancreatography- a test where a scope passed through the stomach into the duodenum is used to inject dye into the bile and pancreatic ducts) to see what is causing my patient’s jaundice symptoms.